HOT or not: examining the basis of high-occupancy target regions
Identifieur interne : 000551 ( Main/Exploration ); précédent : 000550; suivant : 000552HOT or not: examining the basis of high-occupancy target regions
Auteurs : Katarzyna Wreczycka [Allemagne] ; Vedran Franke [Allemagne] ; Bora Uyar [Allemagne] ; Ricardo Wurmus [Allemagne] ; Selman Bulut [Allemagne] ; Baris Tursun [Allemagne] ; Altuna Akalin [Allemagne]Source :
- Nucleic Acids Research [ 0305-1048 ] ; 2019.
Descripteurs français
- KwdFr :
- ADN (), ARN (), Analyse de séquence d'ADN, Animaux, Artéfacts, Caenorhabditis elegans, Domaines protéiques, Drosophila melanogaster, Facteurs de transcription (), Faux positifs, G-quadruplexes, Génome, Génome humain, Génomique, Humains, Immunoprécipitation de la chromatine (), Liaison aux protéines, Motifs d'acides aminés, Régions promotrices (génétique), Sites de fixation, Souris.
- MESH :
- ADN, ARN, Analyse de séquence d'ADN, Animaux, Artéfacts, Caenorhabditis elegans, Domaines protéiques, Drosophila melanogaster, Facteurs de transcription, Faux positifs, G-quadruplexes, Génome, Génome humain, Génomique, Humains, Immunoprécipitation de la chromatine, Liaison aux protéines, Motifs d'acides aminés, Régions promotrices (génétique), Sites de fixation, Souris.
English descriptors
- KwdEn :
- Amino Acid Motifs, Animals, Artifacts, Binding Sites, Caenorhabditis elegans, Chromatin Immunoprecipitation (methods), DNA (chemistry), Drosophila melanogaster, False Positive Reactions, G-Quadruplexes, Genome, Genome, Human, Genomics, Humans, Mice, Promoter Regions, Genetic, Protein Binding, Protein Domains, RNA (chemistry), Sequence Analysis, DNA, Transcription Factors (chemistry).
- MESH :
- chemical , chemistry : DNA, RNA, Transcription Factors.
- methods : Chromatin Immunoprecipitation.
- Amino Acid Motifs, Animals, Artifacts, Binding Sites, Caenorhabditis elegans, Drosophila melanogaster, False Positive Reactions, G-Quadruplexes, Genome, Genome, Human, Genomics, Humans, Mice, Promoter Regions, Genetic, Protein Binding, Protein Domains, Sequence Analysis, DNA.
Abstract
High-occupancy target (HOT) regions are segments of the genome with unusually high number of transcription factor binding sites. These regions are observed in multiple species and thought to have biological importance due to high transcription factor occupancy. Furthermore, they coincide with house-keeping gene promoters and consequently associated genes are stably expressed across multiple cell types. Despite these features, HOT regions are solely defined using ChIP-seq experiments and shown to lack canonical motifs for transcription factors that are thought to be bound there. Although, ChIP-seq experiments are the golden standard for finding genome-wide binding sites of a protein, they are not noise free. Here, we show that HOT regions are likely to be ChIP-seq artifacts and they are similar to previously proposed ‘hyper-ChIPable’ regions. Using ChIP-seq data sets for knocked-out transcription factors, we demonstrate presence of false positive signals on HOT regions. We observe sequence characteristics and genomic features that are discriminatory of HOT regions, such as GC/CpG-rich k-mers, enrichment of RNA–DNA hybrids (R-loops) and DNA tertiary structures (G-quadruplex DNA). The artificial ChIP-seq enrichment on HOT regions could be associated to these discriminatory features. Furthermore, we propose strategies to deal with such artifacts for the future ChIP-seq studies.
Url:
DOI: 10.1093/nar/gkz460
PubMed: 31114922
PubMed Central: 6582337
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000F62
- to stream Pmc, to step Curation: 000F62
- to stream Pmc, to step Checkpoint: 000293
- to stream PubMed, to step Corpus: 000531
- to stream PubMed, to step Curation: 000531
- to stream PubMed, to step Checkpoint: 000540
- to stream Ncbi, to step Merge: 002226
- to stream Ncbi, to step Curation: 002226
- to stream Ncbi, to step Checkpoint: 002226
- to stream Main, to step Merge: 000554
- to stream Main, to step Curation: 000551
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">HOT or not: examining the basis of high-occupancy target regions</title><author><name sortKey="Wreczycka, Katarzyna" sort="Wreczycka, Katarzyna" uniqKey="Wreczycka K" first="Katarzyna" last="Wreczycka">Katarzyna Wreczycka</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Franke, Vedran" sort="Franke, Vedran" uniqKey="Franke V" first="Vedran" last="Franke">Vedran Franke</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Uyar, Bora" sort="Uyar, Bora" uniqKey="Uyar B" first="Bora" last="Uyar">Bora Uyar</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Wurmus, Ricardo" sort="Wurmus, Ricardo" uniqKey="Wurmus R" first="Ricardo" last="Wurmus">Ricardo Wurmus</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Bulut, Selman" sort="Bulut, Selman" uniqKey="Bulut S" first="Selman" last="Bulut">Selman Bulut</name><affiliation wicri:level="3"><nlm:aff id="AFF2">Gene Regulation and Cell Fate Decision in<italic>C. elegans</italic>, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Tursun, Baris" sort="Tursun, Baris" uniqKey="Tursun B" first="Baris" last="Tursun">Baris Tursun</name><affiliation wicri:level="3"><nlm:aff id="AFF2">Gene Regulation and Cell Fate Decision in<italic>C. elegans</italic>, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Akalin, Altuna" sort="Akalin, Altuna" uniqKey="Akalin A" first="Altuna" last="Akalin">Altuna Akalin</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31114922</idno><idno type="pmc">6582337</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582337</idno><idno type="RBID">PMC:6582337</idno><idno type="doi">10.1093/nar/gkz460</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000F62</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F62</idno><idno type="wicri:Area/Pmc/Curation">000F62</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000F62</idno><idno type="wicri:Area/Pmc/Checkpoint">000293</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000293</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:31114922</idno><idno type="wicri:Area/PubMed/Corpus">000531</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000531</idno><idno type="wicri:Area/PubMed/Curation">000531</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000531</idno><idno type="wicri:Area/PubMed/Checkpoint">000540</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000540</idno><idno type="wicri:Area/Ncbi/Merge">002226</idno><idno type="wicri:Area/Ncbi/Curation">002226</idno><idno type="wicri:Area/Ncbi/Checkpoint">002226</idno><idno type="wicri:doubleKey">0305-1048:2019:Wreczycka K:hot:or:not</idno><idno type="wicri:Area/Main/Merge">000554</idno><idno type="wicri:Area/Main/Curation">000551</idno><idno type="wicri:Area/Main/Exploration">000551</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">HOT or not: examining the basis of high-occupancy target regions</title><author><name sortKey="Wreczycka, Katarzyna" sort="Wreczycka, Katarzyna" uniqKey="Wreczycka K" first="Katarzyna" last="Wreczycka">Katarzyna Wreczycka</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Franke, Vedran" sort="Franke, Vedran" uniqKey="Franke V" first="Vedran" last="Franke">Vedran Franke</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Uyar, Bora" sort="Uyar, Bora" uniqKey="Uyar B" first="Bora" last="Uyar">Bora Uyar</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Wurmus, Ricardo" sort="Wurmus, Ricardo" uniqKey="Wurmus R" first="Ricardo" last="Wurmus">Ricardo Wurmus</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Bulut, Selman" sort="Bulut, Selman" uniqKey="Bulut S" first="Selman" last="Bulut">Selman Bulut</name><affiliation wicri:level="3"><nlm:aff id="AFF2">Gene Regulation and Cell Fate Decision in<italic>C. elegans</italic>, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Tursun, Baris" sort="Tursun, Baris" uniqKey="Tursun B" first="Baris" last="Tursun">Baris Tursun</name><affiliation wicri:level="3"><nlm:aff id="AFF2">Gene Regulation and Cell Fate Decision in<italic>C. elegans</italic>, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Akalin, Altuna" sort="Akalin, Altuna" uniqKey="Akalin A" first="Altuna" last="Akalin">Altuna Akalin</name><affiliation wicri:level="3"><nlm:aff id="AFF1">Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bioinformatics and Omics Data Science Platform, Berlin Institute for Medical Systems Biology, Max-Delbrück Center for Molecular Medicine, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></analytic><series><title level="j">Nucleic Acids Research</title><idno type="ISSN">0305-1048</idno><idno type="eISSN">1362-4962</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Motifs</term><term>Animals</term><term>Artifacts</term><term>Binding Sites</term><term>Caenorhabditis elegans</term><term>Chromatin Immunoprecipitation (methods)</term><term>DNA (chemistry)</term><term>Drosophila melanogaster</term><term>False Positive Reactions</term><term>G-Quadruplexes</term><term>Genome</term><term>Genome, Human</term><term>Genomics</term><term>Humans</term><term>Mice</term><term>Promoter Regions, Genetic</term><term>Protein Binding</term><term>Protein Domains</term><term>RNA (chemistry)</term><term>Sequence Analysis, DNA</term><term>Transcription Factors (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN ()</term><term>ARN ()</term><term>Analyse de séquence d'ADN</term><term>Animaux</term><term>Artéfacts</term><term>Caenorhabditis elegans</term><term>Domaines protéiques</term><term>Drosophila melanogaster</term><term>Facteurs de transcription ()</term><term>Faux positifs</term><term>G-quadruplexes</term><term>Génome</term><term>Génome humain</term><term>Génomique</term><term>Humains</term><term>Immunoprécipitation de la chromatine ()</term><term>Liaison aux protéines</term><term>Motifs d'acides aminés</term><term>Régions promotrices (génétique)</term><term>Sites de fixation</term><term>Souris</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>DNA</term><term>RNA</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromatin Immunoprecipitation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Motifs</term><term>Animals</term><term>Artifacts</term><term>Binding Sites</term><term>Caenorhabditis elegans</term><term>Drosophila melanogaster</term><term>False Positive Reactions</term><term>G-Quadruplexes</term><term>Genome</term><term>Genome, Human</term><term>Genomics</term><term>Humans</term><term>Mice</term><term>Promoter Regions, Genetic</term><term>Protein Binding</term><term>Protein Domains</term><term>Sequence Analysis, DNA</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ADN</term><term>ARN</term><term>Analyse de séquence d'ADN</term><term>Animaux</term><term>Artéfacts</term><term>Caenorhabditis elegans</term><term>Domaines protéiques</term><term>Drosophila melanogaster</term><term>Facteurs de transcription</term><term>Faux positifs</term><term>G-quadruplexes</term><term>Génome</term><term>Génome humain</term><term>Génomique</term><term>Humains</term><term>Immunoprécipitation de la chromatine</term><term>Liaison aux protéines</term><term>Motifs d'acides aminés</term><term>Régions promotrices (génétique)</term><term>Sites de fixation</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>High-occupancy target (HOT) regions are segments of the genome with unusually high number of transcription factor binding sites. These regions are observed in multiple species and thought to have biological importance due to high transcription factor occupancy. Furthermore, they coincide with house-keeping gene promoters and consequently associated genes are stably expressed across multiple cell types. Despite these features, HOT regions are solely defined using ChIP-seq experiments and shown to lack canonical motifs for transcription factors that are thought to be bound there. Although, ChIP-seq experiments are the golden standard for finding genome-wide binding sites of a protein, they are not noise free. Here, we show that HOT regions are likely to be ChIP-seq artifacts and they are similar to previously proposed ‘hyper-ChIPable’ regions. Using ChIP-seq data sets for knocked-out transcription factors, we demonstrate presence of false positive signals on HOT regions. We observe sequence characteristics and genomic features that are discriminatory of HOT regions, such as GC/CpG-rich k-mers, enrichment of RNA–DNA hybrids (R-loops) and DNA tertiary structures (G-quadruplex DNA). The artificial ChIP-seq enrichment on HOT regions could be associated to these discriminatory features. Furthermore, we propose strategies to deal with such artifacts for the future ChIP-seq studies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Celniker, S E" uniqKey="Celniker S">S.E. Celniker</name></author><author><name sortKey="Dillon, L A L" uniqKey="Dillon L">L.A.L. Dillon</name></author><author><name sortKey="Gerstein, M B" uniqKey="Gerstein M">M.B. Gerstein</name></author><author><name sortKey="Gunsalus, K C" uniqKey="Gunsalus K">K.C. Gunsalus</name></author><author><name sortKey="Henikoff, S" uniqKey="Henikoff S">S. Henikoff</name></author><author><name sortKey="Karpen, G H" uniqKey="Karpen G">G.H. Karpen</name></author><author><name sortKey="Kellis, M" uniqKey="Kellis M">M. Kellis</name></author><author><name sortKey="Lai, E C" uniqKey="Lai E">E.C. Lai</name></author><author><name sortKey="Lieb, J D" uniqKey="Lieb J">J.D. Lieb</name></author><author><name sortKey="Macalpine, D M" uniqKey="Macalpine D">D.M. MacAlpine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, D" uniqKey="Xie D">D. Xie</name></author><author><name sortKey="Dan, X" uniqKey="Dan X">X. Dan</name></author><author><name sortKey="Boyle, A P" uniqKey="Boyle A">A.P. Boyle</name></author><author><name sortKey="Linfeng, W" uniqKey="Linfeng W">W. Linfeng</name></author><author><name sortKey="Jie, Z" uniqKey="Jie Z">Z. Jie</name></author><author><name sortKey="Trupti, K" uniqKey="Trupti K">K. Trupti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boyle, A P" uniqKey="Boyle A">A.P. Boyle</name></author><author><name sortKey="Araya, C L" uniqKey="Araya C">C.L. Araya</name></author><author><name sortKey="Cathleen, B" uniqKey="Cathleen B">B. Cathleen</name></author><author><name sortKey="Philip, C" uniqKey="Philip C">C. Philip</name></author><author><name sortKey="Chao, C" uniqKey="Chao C">C. Chao</name></author><author><name sortKey="Yong, C" uniqKey="Yong C">C. Yong</name></author><author><name sortKey="Gardner, K" uniqKey="Gardner K">K. Gardner</name></author><author><name sortKey="Hillier, L W" uniqKey="Hillier L">L.W. Hillier</name></author><author><name sortKey="Janette, J" uniqKey="Janette J">J. Janette</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yip, K Y" uniqKey="Yip K">K.Y. Yip</name></author><author><name sortKey="Cheng, C" uniqKey="Cheng C">C. Cheng</name></author><author><name sortKey="Bhardwaj, N" uniqKey="Bhardwaj N">N. Bhardwaj</name></author><author><name sortKey="Brown, J B" uniqKey="Brown J">J.B. Brown</name></author><author><name sortKey="Leng, J" uniqKey="Leng J">J. Leng</name></author><author><name sortKey="Kundaje, A" uniqKey="Kundaje A">A. Kundaje</name></author><author><name sortKey="Rozowsky, J" uniqKey="Rozowsky J">J. Rozowsky</name></author><author><name sortKey="Birney, E" uniqKey="Birney E">E. Birney</name></author><author><name sortKey="Bickel, P" uniqKey="Bickel P">P. Bickel</name></author><author><name sortKey="Snyder, M" uniqKey="Snyder M">M. Snyder</name></author><author><name sortKey="Gerstein, M" uniqKey="Gerstein M">M. Gerstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Afek, A" uniqKey="Afek A">A. Afek</name></author><author><name sortKey="Ariel, A" uniqKey="Ariel A">A. Ariel</name></author><author><name sortKey="Schipper, J L" uniqKey="Schipper J">J.L. Schipper</name></author><author><name sortKey="John, H" uniqKey="John H">H. John</name></author><author><name sortKey="Raluca, G" uniqKey="Raluca G">G. Raluca</name></author><author><name sortKey="Lukatsky, D B" uniqKey="Lukatsky D">D.B. Lukatsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teytelman, L" uniqKey="Teytelman L">L. Teytelman</name></author><author><name sortKey="Thurtle, D M" uniqKey="Thurtle D">D.M. Thurtle</name></author><author><name sortKey="Rine, J" uniqKey="Rine J">J. Rine</name></author><author><name sortKey="Van Oudenaarden, A" uniqKey="Van Oudenaarden A">A. van Oudenaarden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanz, L A" uniqKey="Sanz L">L.A. Sanz</name></author><author><name sortKey="Hartono, S R" uniqKey="Hartono S">S.R. Hartono</name></author><author><name sortKey="Lim, Y W" uniqKey="Lim Y">Y.W. Lim</name></author><author><name sortKey="Steyaert, S" uniqKey="Steyaert S">S. Steyaert</name></author><author><name sortKey="Rajpurkar, A" uniqKey="Rajpurkar A">A. Rajpurkar</name></author><author><name sortKey="Ginno, P A" uniqKey="Ginno P">P.A. Ginno</name></author><author><name sortKey="Xu, X" uniqKey="Xu X">X. Xu</name></author><author><name sortKey="Chedin, F" uniqKey="Chedin F">F. Chédin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerstein, M B" uniqKey="Gerstein M">M.B. Gerstein</name></author><author><name sortKey="Lu, Z J" uniqKey="Lu Z">Z.J. Lu</name></author><author><name sortKey="Van Nostrand, E L" uniqKey="Van Nostrand E">E.L. Van Nostrand</name></author><author><name sortKey="Cheng, C" uniqKey="Cheng C">C. Cheng</name></author><author><name sortKey="Arshinoff, B I" uniqKey="Arshinoff B">B.I. Arshinoff</name></author><author><name sortKey="Liu, T" uniqKey="Liu T">T. Liu</name></author><author><name sortKey="Yip, K Y" uniqKey="Yip K">K.Y. Yip</name></author><author><name sortKey="Robilotto, R" uniqKey="Robilotto R">R. Robilotto</name></author><author><name sortKey="Rechtsteiner, A" uniqKey="Rechtsteiner A">A. Rechtsteiner</name></author><author><name sortKey="Ikegami, K" uniqKey="Ikegami K">K. Ikegami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mclean, C Y" uniqKey="Mclean C">C.Y. McLean</name></author><author><name sortKey="Dave, B" uniqKey="Dave B">B. Dave</name></author><author><name sortKey="Michael, H" uniqKey="Michael H">H. Michael</name></author><author><name sortKey="Clarke, S L" uniqKey="Clarke S">S.L. Clarke</name></author><author><name sortKey="Schaar, B T" uniqKey="Schaar B">B.T. Schaar</name></author><author><name sortKey="Lowe, C B" uniqKey="Lowe C">C.B. Lowe</name></author><author><name sortKey="Wenger, A M" uniqKey="Wenger A">A.M. Wenger</name></author><author><name sortKey="Bejerano, G" uniqKey="Bejerano G">G. Bejerano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forrest, A R R" uniqKey="Forrest A">A.R.R. Forrest</name></author><author><name sortKey="Kawaji, H" uniqKey="Kawaji H">H. Kawaji</name></author><author><name sortKey="Rehli, M" uniqKey="Rehli M">M. Rehli</name></author><author><name sortKey="Baillie, J K" uniqKey="Baillie J">J.K. Baillie</name></author><author><name sortKey="De Hoon, M J L" uniqKey="De Hoon M">M.J.L. de Hoon</name></author><author><name sortKey="Haberle, V" uniqKey="Haberle V">V. Haberle</name></author><author><name sortKey="Lassmann, T" uniqKey="Lassmann T">T. Lassmann</name></author><author><name sortKey="Kulakovskiy, I V" uniqKey="Kulakovskiy I">I.V. Kulakovskiy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yao, Z" uniqKey="Yao Z">Z. Yao</name></author><author><name sortKey="Macquarrie, K L" uniqKey="Macquarrie K">K.L. Macquarrie</name></author><author><name sortKey="Fong, A P" uniqKey="Fong A">A.P. Fong</name></author><author><name sortKey="Tapscott, S J" uniqKey="Tapscott S">S.J. Tapscott</name></author><author><name sortKey="Ruzzo, W L" uniqKey="Ruzzo W">W.L. Ruzzo</name></author><author><name sortKey="Gentleman, R C" uniqKey="Gentleman R">R.C. Gentleman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Friedman, J" uniqKey="Friedman J">J. Friedman</name></author><author><name sortKey="Hastie, T" uniqKey="Hastie T">T. Hastie</name></author><author><name sortKey="Tibshirani, R" uniqKey="Tibshirani R">R. Tibshirani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akalin, A" uniqKey="Akalin A">A. Akalin</name></author><author><name sortKey="Franke, V" uniqKey="Franke V">V. Franke</name></author><author><name sortKey="Vlahovi Ek, K" uniqKey="Vlahovi Ek K">K. Vlahoviček</name></author><author><name sortKey="Mason, C E" uniqKey="Mason C">C.E. Mason</name></author><author><name sortKey="Schubeler, D" uniqKey="Schubeler D">D. Schübeler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kundaje, A" uniqKey="Kundaje A">A. Kundaje</name></author><author><name sortKey="Meuleman, W" uniqKey="Meuleman W">W. Meuleman</name></author><author><name sortKey="Ernst, J" uniqKey="Ernst J">J. Ernst</name></author><author><name sortKey="Bilenky, M" uniqKey="Bilenky M">M. Bilenky</name></author><author><name sortKey="Yen, A" uniqKey="Yen A">A. Yen</name></author><author><name sortKey="Heravi Moussavi, A" uniqKey="Heravi Moussavi A">A. Heravi-Moussavi</name></author><author><name sortKey="Kheradpour, P" uniqKey="Kheradpour P">P. Kheradpour</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z. Zhang</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Eddy, S R" uniqKey="Eddy S">S.R. Eddy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Punta, M" uniqKey="Punta M">M. Punta</name></author><author><name sortKey="Coggill, P C" uniqKey="Coggill P">P.C. Coggill</name></author><author><name sortKey="Eberhardt, R Y" uniqKey="Eberhardt R">R.Y. Eberhardt</name></author><author><name sortKey="Mistry, J" uniqKey="Mistry J">J. Mistry</name></author><author><name sortKey="Tate, J" uniqKey="Tate J">J. Tate</name></author><author><name sortKey="Boursnell, C" uniqKey="Boursnell C">C. Boursnell</name></author><author><name sortKey="Pang, N" uniqKey="Pang N">N. Pang</name></author><author><name sortKey="Forslund, K" uniqKey="Forslund K">K. Forslund</name></author><author><name sortKey="Ceric, G" uniqKey="Ceric G">G. Ceric</name></author><author><name sortKey="Clements, J" uniqKey="Clements J">J. Clements</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, B" uniqKey="Turner B">B. Turner</name></author><author><name sortKey="Razick, S" uniqKey="Razick S">S. Razick</name></author><author><name sortKey="Turinsky, A L" uniqKey="Turinsky A">A.L. Turinsky</name></author><author><name sortKey="Vlasblom, J" uniqKey="Vlasblom J">J. Vlasblom</name></author><author><name sortKey="Crowdy, E K" uniqKey="Crowdy E">E.K. Crowdy</name></author><author><name sortKey="Cho, E" uniqKey="Cho E">E. Cho</name></author><author><name sortKey="Morrison, K" uniqKey="Morrison K">K. Morrison</name></author><author><name sortKey="Donaldson, I M" uniqKey="Donaldson I">I.M. Donaldson</name></author><author><name sortKey="Wodak, S J" uniqKey="Wodak S">S.J. Wodak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, R A J" uniqKey="Chen R">R.A.-J. Chen</name></author><author><name sortKey="Stempor, P" uniqKey="Stempor P">P. Stempor</name></author><author><name sortKey="Down, T A" uniqKey="Down T">T.A. Down</name></author><author><name sortKey="Zeiser, E" uniqKey="Zeiser E">E. Zeiser</name></author><author><name sortKey="Feuer, S K" uniqKey="Feuer S">S.K. Feuer</name></author><author><name sortKey="Ahringer, J" uniqKey="Ahringer J">J. Ahringer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jain, D" uniqKey="Jain D">D. Jain</name></author><author><name sortKey="Dhawal, J" uniqKey="Dhawal J">J. Dhawal</name></author><author><name sortKey="Sandro, B" uniqKey="Sandro B">B. Sandro</name></author><author><name sortKey="Angelika, Z" uniqKey="Angelika Z">Z. Angelika</name></author><author><name sortKey="Tobias, S" uniqKey="Tobias S">S. Tobias</name></author><author><name sortKey="Becker, P B" uniqKey="Becker P">P.B. Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, D" uniqKey="Park D">D. Park</name></author><author><name sortKey="Daechan, P" uniqKey="Daechan P">P. Daechan</name></author><author><name sortKey="Yaelim, L" uniqKey="Yaelim L">L. Yaelim</name></author><author><name sortKey="Gurvani, B" uniqKey="Gurvani B">B. Gurvani</name></author><author><name sortKey="Iyer, V R" uniqKey="Iyer V">V.R. Iyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerstein, M B" uniqKey="Gerstein M">M.B. Gerstein</name></author><author><name sortKey="Lu, Z J" uniqKey="Lu Z">Z.J. Lu</name></author><author><name sortKey="Van Nostrand, E L" uniqKey="Van Nostrand E">E.L. Van Nostrand</name></author><author><name sortKey="Cheng, C" uniqKey="Cheng C">C. Cheng</name></author><author><name sortKey="Arshinoff, B I" uniqKey="Arshinoff B">B.I. Arshinoff</name></author><author><name sortKey="Liu, T" uniqKey="Liu T">T. Liu</name></author><author><name sortKey="Yip, K Y" uniqKey="Yip K">K.Y. Yip</name></author><author><name sortKey="Robilotto, R" uniqKey="Robilotto R">R. Robilotto</name></author><author><name sortKey="Rechtsteiner, A" uniqKey="Rechtsteiner A">A. Rechtsteiner</name></author><author><name sortKey="Ikegami, K" uniqKey="Ikegami K">K. Ikegami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zou, H" uniqKey="Zou H">H. Zou</name></author><author><name sortKey="Hui, Z" uniqKey="Hui Z">Z. Hui</name></author><author><name sortKey="Trevor, H" uniqKey="Trevor H">H. Trevor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Santos Pereira, J M" uniqKey="Santos Pereira J">J.M. Santos-Pereira</name></author><author><name sortKey="Aguilera, A" uniqKey="Aguilera A">A. Aguilera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ginno, P A" uniqKey="Ginno P">P.A. Ginno</name></author><author><name sortKey="Lim, Y W" uniqKey="Lim Y">Y.W. Lim</name></author><author><name sortKey="Lott, P L" uniqKey="Lott P">P.L. Lott</name></author><author><name sortKey="Korf, I" uniqKey="Korf I">I. Korf</name></author><author><name sortKey="Chedin, F" uniqKey="Chedin F">F. Chédin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skourti Stathaki, K" uniqKey="Skourti Stathaki K">K. Skourti-Stathaki</name></author><author><name sortKey="Proudfoot, N J" uniqKey="Proudfoot N">N.J. Proudfoot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Manley, J L" uniqKey="Manley J">J.L. Manley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ginno, P A" uniqKey="Ginno P">P.A. Ginno</name></author><author><name sortKey="Lott, P L" uniqKey="Lott P">P.L. Lott</name></author><author><name sortKey="Christensen, H C" uniqKey="Christensen H">H.C. Christensen</name></author><author><name sortKey="Korf, I" uniqKey="Korf I">I. Korf</name></author><author><name sortKey="Chedin, F" uniqKey="Chedin F">F. Chédin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lima, W F" uniqKey="Lima W">W.F. Lima</name></author><author><name sortKey="Murray, H M" uniqKey="Murray H">H.M. Murray</name></author><author><name sortKey="Damle, S S" uniqKey="Damle S">S.S. Damle</name></author><author><name sortKey="Hart, C E" uniqKey="Hart C">C.E. Hart</name></author><author><name sortKey="Hung, G" uniqKey="Hung G">G. Hung</name></author><author><name sortKey="De Hoyos, C L" uniqKey="De Hoyos C">C.L. De Hoyos</name></author><author><name sortKey="Liang, X H" uniqKey="Liang X">X.H. Liang</name></author><author><name sortKey="Crooke, S T" uniqKey="Crooke S">S.T. Crooke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lim, Y W" uniqKey="Lim Y">Y.W. Lim</name></author><author><name sortKey="Sanz, L A" uniqKey="Sanz L">L.A. Sanz</name></author><author><name sortKey="Xu, X" uniqKey="Xu X">X. Xu</name></author><author><name sortKey="Hartono, S R" uniqKey="Hartono S">S.R. Hartono</name></author><author><name sortKey="Chedin, F" uniqKey="Chedin F">F. Chédin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zeller, P" uniqKey="Zeller P">P. Zeller</name></author><author><name sortKey="Padeken, J" uniqKey="Padeken J">J. Padeken</name></author><author><name sortKey="Van Schendel, R" uniqKey="Van Schendel R">R. van Schendel</name></author><author><name sortKey="Kalck, V" uniqKey="Kalck V">V. Kalck</name></author><author><name sortKey="Tijsterman, M" uniqKey="Tijsterman M">M. Tijsterman</name></author><author><name sortKey="Gasser, S M" uniqKey="Gasser S">S.M. Gasser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="H Nsel Hertsch, R" uniqKey="H Nsel Hertsch R">R. Hänsel-Hertsch</name></author><author><name sortKey="Beraldi, D" uniqKey="Beraldi D">D. Beraldi</name></author><author><name sortKey="Lensing, S V" uniqKey="Lensing S">S.V. Lensing</name></author><author><name sortKey="Marsico, G" uniqKey="Marsico G">G. Marsico</name></author><author><name sortKey="Zyner, K" uniqKey="Zyner K">K. Zyner</name></author><author><name sortKey="Parry, A" uniqKey="Parry A">A. Parry</name></author><author><name sortKey="Di Antonio, M" uniqKey="Di Antonio M">M. Di Antonio</name></author><author><name sortKey="Pike, J" uniqKey="Pike J">J. Pike</name></author><author><name sortKey="Kimura, H" uniqKey="Kimura H">H. Kimura</name></author><author><name sortKey="Narita, M" uniqKey="Narita M">M. Narita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wahba, L" uniqKey="Wahba L">L. Wahba</name></author><author><name sortKey="Costantino, L" uniqKey="Costantino L">L. Costantino</name></author><author><name sortKey="Tan, F J" uniqKey="Tan F">F.J. Tan</name></author><author><name sortKey="Zimmer, A" uniqKey="Zimmer A">A. Zimmer</name></author><author><name sortKey="Koshland, D" uniqKey="Koshland D">D. Koshland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deaton, A M" uniqKey="Deaton A">A.M. Deaton</name></author><author><name sortKey="Bird, A" uniqKey="Bird A">A. Bird</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kidder, B L" uniqKey="Kidder B">B.L. Kidder</name></author><author><name sortKey="Hu, G" uniqKey="Hu G">G. Hu</name></author><author><name sortKey="Zhao, K" uniqKey="Zhao K">K. Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weitzmann, M N" uniqKey="Weitzmann M">M.N. Weitzmann</name></author><author><name sortKey="Savage, N" uniqKey="Savage N">N. Savage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalsi, J K" uniqKey="Kalsi J">J.K. Kalsi</name></author><author><name sortKey="Martin, A C" uniqKey="Martin A">A.C. Martin</name></author><author><name sortKey="Hirabayashi, Y" uniqKey="Hirabayashi Y">Y. Hirabayashi</name></author><author><name sortKey="Ehrenstein, M" uniqKey="Ehrenstein M">M. Ehrenstein</name></author><author><name sortKey="Longhurst, C M" uniqKey="Longhurst C">C.M. Longhurst</name></author><author><name sortKey="Ravirajan, C" uniqKey="Ravirajan C">C. Ravirajan</name></author><author><name sortKey="Zvelebil, M" uniqKey="Zvelebil M">M. Zvelebil</name></author><author><name sortKey="Stollar, B D" uniqKey="Stollar B">B.D. Stollar</name></author><author><name sortKey="Thornton, J M" uniqKey="Thornton J">J.M. Thornton</name></author><author><name sortKey="Isenberg, D A" uniqKey="Isenberg D">D.A. Isenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duquette, M L" uniqKey="Duquette M">M.L. Duquette</name></author><author><name sortKey="Handa, P" uniqKey="Handa P">P. Handa</name></author><author><name sortKey="Vincent, J A" uniqKey="Vincent J">J.A. Vincent</name></author><author><name sortKey="Taylor, A F" uniqKey="Taylor A">A.F. Taylor</name></author><author><name sortKey="Maizels, N" uniqKey="Maizels N">N. Maizels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Mi, J" uniqKey="Mi J">J. Mi</name></author><author><name sortKey="Cao, X" uniqKey="Cao X">X. Cao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braun, R P" uniqKey="Braun R">R.P. Braun</name></author><author><name sortKey="Lee, J S" uniqKey="Lee J">J.S. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, H" uniqKey="Jin H">H. Jin</name></author><author><name sortKey="Sepulveda, J" uniqKey="Sepulveda J">J. Sepúlveda</name></author><author><name sortKey="Burrone, O R" uniqKey="Burrone O">O.R. Burrone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barbas, S M" uniqKey="Barbas S">S.M. Barbas</name></author><author><name sortKey="Ditzel, H J" uniqKey="Ditzel H">H.J. Ditzel</name></author><author><name sortKey="Salonen, E M" uniqKey="Salonen E">E.M. Salonen</name></author><author><name sortKey="Yang, W P" uniqKey="Yang W">W.P. Yang</name></author><author><name sortKey="Silverman, G J" uniqKey="Silverman G">G.J. Silverman</name></author><author><name sortKey="Burton, D R" uniqKey="Burton D">D.R. Burton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cerutti, M L" uniqKey="Cerutti M">M.L. Cerutti</name></author><author><name sortKey="Zarebski, L M" uniqKey="Zarebski L">L.M. Zarebski</name></author><author><name sortKey="De Prat Gay, G" uniqKey="De Prat Gay G">G. de Prat Gay</name></author><author><name sortKey="Goldbaum, F A" uniqKey="Goldbaum F">F.A. Goldbaum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moens, U" uniqKey="Moens U">U. Moens</name></author><author><name sortKey="Mathiesen, I" uniqKey="Mathiesen I">I. Mathiesen</name></author><author><name sortKey="Ghelue, M V" uniqKey="Ghelue M">M.V. Ghelue</name></author><author><name sortKey="Rekvig, O P" uniqKey="Rekvig O">O.P. Rekvig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moens, U" uniqKey="Moens U">U. Moens</name></author><author><name sortKey="Seternes, O M" uniqKey="Seternes O">O.M. Seternes</name></author><author><name sortKey="Hey, A W" uniqKey="Hey A">A.W. Hey</name></author><author><name sortKey="Silsand, Y" uniqKey="Silsand Y">Y. Silsand</name></author><author><name sortKey="Traavik, T" uniqKey="Traavik T">T. Traavik</name></author><author><name sortKey="Johansen, B" uniqKey="Johansen B">B. Johansen</name></author><author><name sortKey="Rekvig, O P" uniqKey="Rekvig O">O.P. Rekvig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voynova, E N" uniqKey="Voynova E">E.N. Voynova</name></author><author><name sortKey="Tchorbanov, A I" uniqKey="Tchorbanov A">A.I. Tchorbanov</name></author><author><name sortKey="Todorov, T A" uniqKey="Todorov T">T.A. Todorov</name></author><author><name sortKey="Vassilev, T L" uniqKey="Vassilev T">T.L. Vassilev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deocharan, B" uniqKey="Deocharan B">B. Deocharan</name></author><author><name sortKey="Qing, X" uniqKey="Qing X">X. Qing</name></author><author><name sortKey="Beger, E" uniqKey="Beger E">E. Beger</name></author><author><name sortKey="Putterman, C" uniqKey="Putterman C">C. Putterman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sciascia, S A" uniqKey="Sciascia S">S.A. Sciascia</name></author><author><name sortKey="Robson, K" uniqKey="Robson K">K. Robson</name></author><author><name sortKey="Zhu, L" uniqKey="Zhu L">L. Zhu</name></author><author><name sortKey="Garland, M" uniqKey="Garland M">M. Garland</name></author><author><name sortKey="Grabosch, S" uniqKey="Grabosch S">S. Grabosch</name></author><author><name sortKey="Kelamis, J" uniqKey="Kelamis J">J. Kelamis</name></author><author><name sortKey="Messamore, W" uniqKey="Messamore W">W. Messamore</name></author><author><name sortKey="Bradley, T" uniqKey="Bradley T">T. Bradley</name></author><author><name sortKey="Sourk, A" uniqKey="Sourk A">A. Sourk</name></author><author><name sortKey="Westberg, L" uniqKey="Westberg L">L. Westberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marchini, B" uniqKey="Marchini B">B. Marchini</name></author><author><name sortKey="Puccetti, A" uniqKey="Puccetti A">A. Puccetti</name></author><author><name sortKey="Dolcher, M P" uniqKey="Dolcher M">M.P. Dolcher</name></author><author><name sortKey="Madaio, M P" uniqKey="Madaio M">M.P. Madaio</name></author><author><name sortKey="Migliorini, P" uniqKey="Migliorini P">P. Migliorini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Desai, D D" uniqKey="Desai D">D.D. Desai</name></author><author><name sortKey="Krishnan, M R" uniqKey="Krishnan M">M.R. Krishnan</name></author><author><name sortKey="Swindle, J T" uniqKey="Swindle J">J.T. Swindle</name></author><author><name sortKey="Marion, T N" uniqKey="Marion T">T.N. Marion</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tran, T T" uniqKey="Tran T">T.T. Tran</name></author><author><name sortKey="Reich, C F" uniqKey="Reich C">C.F. Reich</name></author><author><name sortKey="Alam, M" uniqKey="Alam M">M. Alam</name></author><author><name sortKey="Pisetsky, D S" uniqKey="Pisetsky D">D.S. Pisetsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petrakova, N" uniqKey="Petrakova N">N. Petrakova</name></author><author><name sortKey="Gudmundsdotter, L" uniqKey="Gudmundsdotter L">L. Gudmundsdotter</name></author><author><name sortKey="Yermalovich, M" uniqKey="Yermalovich M">M. Yermalovich</name></author><author><name sortKey="Belikov, S" uniqKey="Belikov S">S. Belikov</name></author><author><name sortKey="Eriksson, L" uniqKey="Eriksson L">L. Eriksson</name></author><author><name sortKey="Pyakurel, P" uniqKey="Pyakurel P">P. Pyakurel</name></author><author><name sortKey="Johansson, O" uniqKey="Johansson O">O. Johansson</name></author><author><name sortKey="Biberfeld, P" uniqKey="Biberfeld P">P. Biberfeld</name></author><author><name sortKey="Andersson, S" uniqKey="Andersson S">S. Andersson</name></author><author><name sortKey="Isaguliants, M" uniqKey="Isaguliants M">M. Isaguliants</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lakamp, A S" uniqKey="Lakamp A">A.S. Lakamp</name></author><author><name sortKey="Ouellette, M M" uniqKey="Ouellette M">M.M. Ouellette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wun, H L" uniqKey="Wun H">H.L. Wun</name></author><author><name sortKey="Leung, D T" uniqKey="Leung D">D.T. Leung</name></author><author><name sortKey="Wong, K C" uniqKey="Wong K">K.C. Wong</name></author><author><name sortKey="Chui, Y L" uniqKey="Chui Y">Y.L. Chui</name></author><author><name sortKey="Lim, P L" uniqKey="Lim P">P.L. Lim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pisetsky, D S" uniqKey="Pisetsky D">D.S. Pisetsky</name></author><author><name sortKey="Hoch, S O" uniqKey="Hoch S">S.O. Hoch</name></author><author><name sortKey="Klatt, C L" uniqKey="Klatt C">C.L. Klatt</name></author><author><name sortKey="O Onnell, M A" uniqKey="O Onnell M">M.A. O’Donnell</name></author><author><name sortKey="Keene, J D" uniqKey="Keene J">J.D. Keene</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name></author><author><name sortKey="Dang, S" uniqKey="Dang S">S. Dang</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name></author><author><name sortKey="Nardi, M A" uniqKey="Nardi M">M.A. Nardi</name></author><author><name sortKey="Zan, H" uniqKey="Zan H">H. Zan</name></author><author><name sortKey="Casali, P" uniqKey="Casali P">P. Casali</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reichlin, M" uniqKey="Reichlin M">M. Reichlin</name></author><author><name sortKey="Martin, A" uniqKey="Martin A">A. Martin</name></author><author><name sortKey="Taylor Albert, E" uniqKey="Taylor Albert E">E. Taylor-Albert</name></author><author><name sortKey="Tsuzaka, K" uniqKey="Tsuzaka K">K. Tsuzaka</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name></author><author><name sortKey="Reichlin, M W" uniqKey="Reichlin M">M.W. Reichlin</name></author><author><name sortKey="Koren, E" uniqKey="Koren E">E. Koren</name></author><author><name sortKey="Ebling, F M" uniqKey="Ebling F">F.M. Ebling</name></author><author><name sortKey="Tsao, B" uniqKey="Tsao B">B. Tsao</name></author><author><name sortKey="Hahn, B H" uniqKey="Hahn B">B.H. Hahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caponi, L" uniqKey="Caponi L">L. Caponi</name></author><author><name sortKey="Chimenti, D" uniqKey="Chimenti D">D. Chimenti</name></author><author><name sortKey="Pratesi, F" uniqKey="Pratesi F">F. Pratesi</name></author><author><name sortKey="Migliorini, P" uniqKey="Migliorini P">P. Migliorini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yasuda, K" uniqKey="Yasuda K">K. Yasuda</name></author><author><name sortKey="Richez, C" uniqKey="Richez C">C. Richez</name></author><author><name sortKey="Uccellini, M B" uniqKey="Uccellini M">M.B. Uccellini</name></author><author><name sortKey="Richards, R J" uniqKey="Richards R">R.J. Richards</name></author><author><name sortKey="Bonegio, R G" uniqKey="Bonegio R">R.G. Bonegio</name></author><author><name sortKey="Akira, S" uniqKey="Akira S">S. Akira</name></author><author><name sortKey="Monestier, M" uniqKey="Monestier M">M. Monestier</name></author><author><name sortKey="Corley, R B" uniqKey="Corley R">R.B. Corley</name></author><author><name sortKey="Viglianti, G A" uniqKey="Viglianti G">G.A. Viglianti</name></author><author><name sortKey="Marshak Rothstein, A" uniqKey="Marshak Rothstein A">A. Marshak-Rothstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, S" uniqKey="Kumar S">S. Kumar</name></author><author><name sortKey="Hinks, J A" uniqKey="Hinks J">J.A. Hinks</name></author><author><name sortKey="Maman, J" uniqKey="Maman J">J. Maman</name></author><author><name sortKey="Ravirajan, C T" uniqKey="Ravirajan C">C.T. Ravirajan</name></author><author><name sortKey="Pearl, L H" uniqKey="Pearl L">L.H. Pearl</name></author><author><name sortKey="Isenberg, D A" uniqKey="Isenberg D">D.A. Isenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gaynor, B" uniqKey="Gaynor B">B. Gaynor</name></author><author><name sortKey="Putterman, C" uniqKey="Putterman C">C. Putterman</name></author><author><name sortKey="Valadon, P" uniqKey="Valadon P">P. Valadon</name></author><author><name sortKey="Spatz, L" uniqKey="Spatz L">L. Spatz</name></author><author><name sortKey="Scharff, M D" uniqKey="Scharff M">M.D. Scharff</name></author><author><name sortKey="Diamond, B" uniqKey="Diamond B">B. Diamond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lentini, A" uniqKey="Lentini A">A. Lentini</name></author><author><name sortKey="Lagerwall, C" uniqKey="Lagerwall C">C. Lagerwall</name></author><author><name sortKey="Vikingsson, S" uniqKey="Vikingsson S">S. Vikingsson</name></author><author><name sortKey="Mjoseng, H K" uniqKey="Mjoseng H">H.K. Mjoseng</name></author><author><name sortKey="Douvlataniotis, K" uniqKey="Douvlataniotis K">K. Douvlataniotis</name></author><author><name sortKey="Vogt, H" uniqKey="Vogt H">H. Vogt</name></author><author><name sortKey="Green, H" uniqKey="Green H">H. Green</name></author><author><name sortKey="Meehan, R R" uniqKey="Meehan R">R.R. Meehan</name></author><author><name sortKey="Benson, M" uniqKey="Benson M">M. Benson</name></author><author><name sortKey="Nestor, C E" uniqKey="Nestor C">C.E. Nestor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wardle, F C" uniqKey="Wardle F">F.C. Wardle</name></author><author><name sortKey="Tan, H" uniqKey="Tan H">H. Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stormo, G D" uniqKey="Stormo G">G.D. Stormo</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y. Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bulyk, M L" uniqKey="Bulyk M">M.L. Bulyk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parseghian, M H" uniqKey="Parseghian M">M.H. Parseghian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uhlen, M" uniqKey="Uhlen M">M. Uhlen</name></author><author><name sortKey="Bandrowski, A" uniqKey="Bandrowski A">A. Bandrowski</name></author><author><name sortKey="Carr, S" uniqKey="Carr S">S. Carr</name></author><author><name sortKey="Edwards, A" uniqKey="Edwards A">A. Edwards</name></author><author><name sortKey="Ellenberg, J" uniqKey="Ellenberg J">J. Ellenberg</name></author><author><name sortKey="Lundberg, E" uniqKey="Lundberg E">E. Lundberg</name></author><author><name sortKey="Rimm, D L" uniqKey="Rimm D">D.L. Rimm</name></author><author><name sortKey="Rodriguez, H" uniqKey="Rodriguez H">H. Rodriguez</name></author><author><name sortKey="Hiltke, T" uniqKey="Hiltke T">T. Hiltke</name></author><author><name sortKey="Snyder, M" uniqKey="Snyder M">M. Snyder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krebs, W" uniqKey="Krebs W">W. Krebs</name></author><author><name sortKey="Schmidt, S V" uniqKey="Schmidt S">S.V. Schmidt</name></author><author><name sortKey="Goren, A" uniqKey="Goren A">A. Goren</name></author><author><name sortKey="De Nardo, D" uniqKey="De Nardo D">D. De Nardo</name></author><author><name sortKey="Labzin, L" uniqKey="Labzin L">L. Labzin</name></author><author><name sortKey="Bovier, A" uniqKey="Bovier A">A. Bovier</name></author><author><name sortKey="Ulas, T" uniqKey="Ulas T">T. Ulas</name></author><author><name sortKey="Theis, H" uniqKey="Theis H">H. Theis</name></author><author><name sortKey="Kraut, M" uniqKey="Kraut M">M. Kraut</name></author><author><name sortKey="Latz, E" uniqKey="Latz E">E. Latz</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Berlin</li></region><settlement><li>Berlin</li></settlement></list><tree><country name="Allemagne"><region name="Berlin"><name sortKey="Wreczycka, Katarzyna" sort="Wreczycka, Katarzyna" uniqKey="Wreczycka K" first="Katarzyna" last="Wreczycka">Katarzyna Wreczycka</name></region><name sortKey="Akalin, Altuna" sort="Akalin, Altuna" uniqKey="Akalin A" first="Altuna" last="Akalin">Altuna Akalin</name><name sortKey="Bulut, Selman" sort="Bulut, Selman" uniqKey="Bulut S" first="Selman" last="Bulut">Selman Bulut</name><name sortKey="Franke, Vedran" sort="Franke, Vedran" uniqKey="Franke V" first="Vedran" last="Franke">Vedran Franke</name><name sortKey="Tursun, Baris" sort="Tursun, Baris" uniqKey="Tursun B" first="Baris" last="Tursun">Baris Tursun</name><name sortKey="Uyar, Bora" sort="Uyar, Bora" uniqKey="Uyar B" first="Bora" last="Uyar">Bora Uyar</name><name sortKey="Wurmus, Ricardo" sort="Wurmus, Ricardo" uniqKey="Wurmus R" first="Ricardo" last="Wurmus">Ricardo Wurmus</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000551 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000551 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6582337
|texte= HOT or not: examining the basis of high-occupancy target regions
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31114922" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |